Topology optimization using TOSCA for Abaqus is executed by running the Abaqus execution procedure and by providing the name of the parameter file, which, in turn, refers to an Abaqus input file. You can define your optimization model using Abaqus/CAE, and you can use the Optimization Process Manager to create the parameter file and the Abaqus/CAE input file.
https://abaqus-docs.mit.edu/2017/English/SIMACAEEXCRefMap/simaexc-c-topooptimizeproc.htm